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The risk of overweight and obesity is higher in patients with psychiatric disorders than in persons without psychiatric disorders. Certain medications may cause weight gain or changes in body composition; these include insulin, sulfonylureas, thiazolidinediones, atypical antipsychotics, antidepressants, steroids.Certain anticonvulsants (phenytoin and valproate), pizotifen, and some forms of hormonal contraception.