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The perfect anti-obesity drug would produce maintained weight loss with minimal side effects. The components that regulate energy balance have substantial built-in excess, overlap considerably with other physiological functions, and are affected by social, hedonic and psychological components that limit the effectiveness of pharmacological interventions. It is hence unsurprising that anti-obesity drug discovery programs have been littered with false begins, disappointments in clinical improvement, and withdrawals due to unfavorable effects that were not completely acknowledged at the time of launch.